Background:

This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia.

Applications:

ELISA, IHC

Name of antibody:

MGP

Immunogen:

Fusion protein of human MGP

Full name:

matrix Gla protein

Synonyms:

NTI; GIG36; MGLAP

SwissProt:

P08493

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil and Human colorectal cancer

IHC Recommend dilution:

70-350