Background:

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.

Applications:

ELISA, WB, IHC

Name of antibody:

MTNR1A

Immunogen:

Synthetic peptide of human MTNR1A

Full name:

melatonin receptor 1A

Synonyms：

MT1, MEL-1A-R

SwissProt:

P48039

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human breast cancer

IHC Recommend dilution:

100-300

WB Predicted band size:

39 kDa

WB Positive control:

NIH/3T3 cells

WB Recommended dilution:

1000-3000