Background:

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Applications:

ELISA, WB

Name of antibody:

RHOC

Immunogen:

Synthetic peptide of human RHOC

Full name:

Ras homolog family member C

Synonyms：

H9, ARH9, ARHC, RHOH9

SwissProt:

P08134

ELISA Recommended dilution:

1000-5000

WB Predicted band size:

22 kDa

WB Positive control:

Human fetal brain tissue

WB Recommended dilution:

500-2000